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After the incubation period, the first signs begin to appear, by which it is quite difficult to identify the presence of the disease. These are constant fatigue, sleep disorders, dyspeptic disorders and muscle pain. icteric stage. During the period of icterus, there is a strong intoxication of the whole organism, the patient's condition worsens. The skin, sclera of the eyes and other mucous membranes begin to turn yellow. The color of the urine changes to dark brown, and the feces become white and clay.